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Confronting the Clinical Challenges of Frontotemporal Dementia
A look at FTD’s symptoms, pathophysiology, subtypes, as well as the latest from imaging studies.
By Zac Haughn, Senior Associate Editor
FEATURES

Case Report: Leber Hereditary Optic Neuropathy in a 60-Year-Old Man with Vitamin B12 Deficiency
LHON should be considered as a diagnosis in patients, regardless of age, with unexplained bilateral optic neuropathy and central vision loss.
By Darby D. Miller, MD, Craig E. Geist, MD, and Charles J. Macri, MD

Neurology Clinical Trials in the Community Hospital Setting
A significant trend, encouraged by NIH, is expanding clinical research to community hospitals with potential benefits for patients and clinicians.
By David M. Brown, MD, and Laura Whitaker, RN
Editor’s Message
By Paul Winnington

Dementia Insights: The Role of Cognitive Fluctuations and Impaired Episodic Memory in the Diagnosis of Dementia: New Considerations
Studies suggest that the presence of cognitive fluctuations and abnormalities in episodic memory and delayed recall can occur in several dementias.
By Ronald Devere, MD

Expert Opinion: Neuropsychological Impairments In Females with Primary Sjögren’s Syndrome: New Insights
The pSS literature has reported varying degrees of central nervous system involvement in individuals with this condition and secondary cognitive deficits associated with the disease.