Biomarkers Available to Speed Diagnosis of Fibromyalgia


Iquity (Nashville, Tennessee) has announced the release of IsolateFibromyalgia, an RNA analysis of blood samples, for the fast and accurate detection of fibromyalgia syndrome.

IsolateFibromyalgia shows, with 94% accuracy, whether a patient’s gene expression pattern is consistent with fibromyalgia and can be ordered from Results are returned within 7 days of receiving a patient’s blood sample, which can reduce the time to diagnosis by months. Previously, IQuity has released similar tests for multiple sclerosis and inflammatory bowel disease. 

These tests were developed using machine-learning methods to create algorithms that compare a patient’s RNA profile to that of healthy subjects and those with specific diseases identified with IQuity’s robust database of gene-expression data. IQuity’s researchers examined approximately 600 samples from patients suffering from a number of conditions, including fibromyalgia, rheumatoid arthritis, systemic lupus, and clinically diagnosed depression, as well as healthy patients.

Fibromyalgia is a disorder of the central nervous system affecting between 6 and 12 million Americans with symptoms that include intense and sometimes debilitating pain throughout the body, fatigue, depression, and difficulty concentrating. Diagnosis has been difficult both because of heterogeneous presentations of the disease and because symptoms mimic several other diseases, including hypothyroidism, sleep apnea, rheumatoid arthritis, lupus, and malignancy.

Symptoms of fibromyalgia may be treated with duloxetine, pregabalin, milnacipran, selective serotonin reuptake inhibitors, exercise, sleep hygiene, bed rest, and other lifestyle changes.  Earlier diagnosis leading to earlier treatment can be expected to improve patients’ quality of life significantly.

“RNA analysis is a cutting-edge tool for doctors that has great potential in the field of medical diagnostics,” said Dr. Chase Spurlock, CEO of IQuity. “Unlike DNA, which can predict the risk of certain diseases, RNA shows what’s taking place right now in a patient’s cells. That information can speed up the pace of diagnosis for physicians, leading to faster, more effective treatment for patients.”

“Living with the pain of fibromyalgia is often compounded with confusion and uncertainty when patients don’t know the cause of their illness,” said Spurlock. “IsolateFibromyalgia provides useful information that improves the efficiency of the diagnostic process for doctors.”


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